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Important Progress in Nano Fluorescent Probe for Rare Earth Metal-Organic Frameworks

By: School of Chemical Science and Engineering  Published:03/15/2017 
A research team led by Professor YAN Bing from the School of Chemical Science and Engineering, Tongji University made important progress in the study of nanofluorescent probes for rare earth metal-organic frameworks(MOFs), which succeeded in efficient biological monitoring of harmful substances.
The team has long been engaged in the study of optical functional hybrid materials and nano-micro solids. They attempted to use a lanthanide-functionalized metal-organic framework sensor as the fluorescent probe to detect biomarkers of toluene, polycyclic aromatic hydrocarbons in urine, which resulted in efficient biological monitoring of harmful substances. Their research results were published in a paperentitled Determination of Urinary 1-Hydroxypyrene for Biomonitoring of Human Exposure to Polycyclic Aromatic Hydrocarbons Carcinogens by a Lanthanide-functionalized Metal-Organic Framework Sensorin the internationally renowned journal of Advanced Functional Materials (Adv. Funct. Mater. 2017, 27, 1603856, JIF11.382).
In the program, a novel nano fluorescent probe based on Eu-functionalized MOFswas designed and synthesized for urinary 1-hydroxypyrene (1-HP), the biomarker of carcinogenic polycyclic aromatic hydrocarbons (PAHs)by means of fluorescence resonance energy transfer. As the first fluorescent probe for detecting 1-HP, it demonstrated unique performances in its high sense of selection, sensitivity, detection speed and recycled use.